비알콜성지방간 환자와 대조군의 영양소 섭취량 및 혈액학적 지표 비교

Abstract

We conducted a multi-center case-control study to investigate associations between dietary factors and non-alcoholic fatty liver disease (NAFLD) among Korean adults aged 20-70 years. A total of 348 subjects were recruited from the 5 participating university hospitals. Information on socio-demographic characteristics and health-related behaviors are obtained through a face-to-face interview using a structured questionnaire. Usual dietary intakes are assessed with a 24-hour recall was conducted by a trained dietitian applying a multiple pass approach, and 4-day food records include 1 or 2 weekend days. The study protocol was approved by the IRB at each participating institution. There were no significant differences in health-related behaviors including physical activity, drinking, and dietary supplement intakes between cases and controls except for smoking behavior. The cases were found older (p<0.01) and more obese(p<0.001), and had higher proportions of elevated TG(male: p<0.001, female: p<0.01), fasting glucose(male: p<0.01, female: p<0.001), and LDL-cholesterol (p<0.001) levels compared to the controls. After adjusting for age group, current job, smoking status, regular exercise frequency and energy intake, the lowest tertile groups for vitamin C (ORT1vsT3=4.23(1.54-11.67, Ptrend=0.014), vitamin K (OR T1vsT3 =3.93 (1.56-9.93, Ptrend=0.014), folate(ORT1vsT3=3.37(1.24-9.19, Ptrend =0.077), omega-3 fatty acids (ORT1vsT3=2.16(0.86-5.42, Ptrend=0.03) showed a statistically significant higher risk for NAFLD in men. In women vitamin K(ORT1vsT3=2.54 (1.01-6.42, Ptrend=0.05) intakes showed a statistically significant beneficial effects. In conclusion NAFLD patients have an elevated risk for multiple metabolic risk factors compared to generally healthy controls, and Adequate intakes of vitamin C, vitamin K, n-3 fatty acids may deliver preventive effects for NAFLD in Korean adults.