비알코올성 지방간질환과 식품군 섭취의 연관성에 대한 환자-대조군 연구

Abstract

ABSTRACT

Association between food group intake and non-alcoholic fatty liver disease (NAFLD) among Korean adults: A case-control study

Han, Jung Mi Department of Food & Nutrition Graduate School Sungshin Women's University

We conducted a multi-center case-control study to investigate associations between food group intake and non-alcoholic fatty liver disease (NAFLD) among Korean adults aged 20-70 years. A total of 348 subjects were recruited from the 5 participating university hospitals. Information on socio-demographic characteristics and health-related behaviors are obtained through a face-to-face interview using a structured questionnaire. Usual food group intakes are assessed with a 24-hour recall was conducted by a trained dietitian applying a multiple pass approach, and 4-day food records including 1 or 2 weekend days. The study protocol was approved by the IRB at each participating institution. There were no significant differences in health-related behaviors including physical activity, drinking, and dietary supplement intakes between cases and controls except for smoking behavior. The cases were found older (p<0.01) and more obese(p<0.001), and had higher proportions of elevated TG(male: p<0.001, female: p<0.01), fasting glucose(male: p<0.01, female: p<0.001), and LDL-cholesterol(p<0.001) levels compared to the controls. After adjusting for age group, current job, smoking status, regular exercise frequency and energy intake, the lowest tertile groups for nuts & seeds(ORT1vsT3=3.66(1.20-11.18), Ptrend=0.007) showed a statistically significant higher risk for NAFLD in men. In women, vegetable(ORT1vsT3=4.11(1.42-11.92), Ptrend=0.004) intakes showed a statistically significant beneficial effects. In conclusion NAFLD patients have an elevated risk for multiple metabolic risk factors compared to generally healthy controls, and adequate intakes of nuts & seeds and vegetables may deliver preventive effects for NAFLD in Korean adults.